Open Access<p>miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling</p>
Author(s) -
Xia Ji,
Hairong Guo,
Shanyu Yin,
Haiyan Du
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s215796
Subject(s) - wnt signaling pathway , tcf4 , microrna , cancer research , western blot , cell growth , tumor progression , catenin , metastasis , suppressor , biology , transcription factor , signal transduction , cancer , microbiology and biotechnology , gene , enhancer , genetics
Dysregulation of microRNAs (miRNAs) has been recognized as a crucial biological event in the development of cervical cancer (CC). miR-139-5p was identified as a significant tumor suppressor in multiple human cancers, leaving its roles and mechanisms in CC absolutely unclear. We aimed to investigate the implication of miR-139-5p in CC progression.