Open AccessSilencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt/β-Catenin And PTEN/AKT Signaling Pathways
Author(s) -
Yongzhi Lu,
Wei Sun,
Liang Zhang,
Junyao Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s215400
Subject(s) - cancer research , glioma , pten , protein kinase b , pi3k/akt/mtor pathway , gene silencing , gene knockdown , biology , catenin , wnt signaling pathway , cyclin d1 , cell growth , apoptosis , signal transduction , cell cycle , microbiology and biotechnology , biochemistry , gene , genetics
Membrane-associated guanylate kinase (MAGUK) with inverted orientation protein 1 (MAGI1) is a novel member of the MAGUK family with a vital role in tumor progression related to invasion and metastasis. However, the function of MAGI1 in glioma is currently unknown. We therefore analyzed the expression of MAGI1 protein in human glioma samples, glioma cell lines and glioma stem cells (GSCs), and explored its effects on glioma cell proliferation and apoptosis.