Open Access<p>FAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma</p>
Author(s) -
Nan Liu,
Haijing Zhou,
Xiupeng Zhang,
Lin Cai,
Jingduo Li,
Jing Zhao,
Yang Liu,
Liang Wang,
Chuifeng Fan,
Ailin Li,
Yuan Miao
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s214731
Subject(s) - mapk/erk pathway , cancer research , immunohistochemistry , cyclin d1 , cell growth , phosphorylation , immunofluorescence , medicine , blot , biology , cell cycle , pathology , cancer , microbiology and biotechnology , immunology , antibody , gene , biochemistry , genetics
FAM163A, also called neuroblastoma-derived secretory protein (NDSP) or C1ORF76, was newly found on chromosome 1q25.2. Previous studies of FAM163A focused on its expression and function in neuroblastoma. However, using an online database, we found that FAM163A may predict poor prognosis in lung squamous cell carcinomas (LUSC). Therefore, the role of FAM163A plays in LUSC needs to be further clarified.