Open Access<p>The Exosome And Breast Cancer Cell Plasticity</p>
Author(s) -
Xiaoyun Mao,
Feng Jin
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s214133
Subject(s) - microvesicles , exosome , breast cancer , cancer , cancer research , plasticity , cancer cell , medicine , cell , metastasis , immunotherapy , biology , microrna , biochemistry , gene , materials science , composite material
Cancer cell plasticity is the ability of cancer cells to reversibly interchange between distinct cell status, which plays a key role in cancer progression. Cancer cell plasticity is now known to be shaped by the secreted nanoparticles termed exosomes which transport proteins and lipids as well as nucleic acids. These aspects have emerged as key determinants of tumor progression and targeting, with approaches such as immunotherapy showing promise in the clinic. While significant strides have been made in this research area, some very interesting questions still warrant more and deeper investigation. We provide a review of the interplay between exosomes and breast cancer cell plasticity, and the potential implication in metastases and drug-resistance.