Open Access<p>Hypoxia-Induced Cleavage Of Soluble ephrinA1 From Cancer Cells Is Mediated By MMP-2 And Associates With Angiogenesis In Oral Squamous Cell Carcinoma</p>
Author(s) -
Tingting Ma,
Lin Wang,
Junlin Wang,
Yanjie Liu,
Yu-Cong Chen,
Hu-Jie He,
Yong Song
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s213252
Subject(s) - angiogenesis , matrix metalloproteinase , western blot , secretion , cancer research , hypoxia (environmental) , paracrine signalling , medicine , pathology , chemistry , receptor , biochemistry , gene , organic chemistry , oxygen
ephrinA1 plays important roles in tumor angiogenesis. Matrix metalloproteases (MMPs) can cleave ephrinA1 from the cell membrane into extracellular environment. However, how soluble ephrinA1 is modulated by hypoxia and whether MMPs participate in this hypoxic process remains to be investigated in detail.