Open Access<p>The Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells</p>
Author(s) -
Reinhard Depping,
Moritz von Fallois,
Yosef Landesman,
Friederike Katharina Kosyna
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s213208
Subject(s) - spheroid , nuclear export signal , microbiology and biotechnology , cancer cell , viability assay , hypoxia (environmental) , cell growth , cell culture , cancer research , cell , signal transduction , biology , chemistry , cancer , cell nucleus , biochemistry , genetics , oxygen , nucleus , organic chemistry
The nucleocytoplasmic transport of macromolecules is critical for both cell physiology and pathophysiology. Exportin 1 (XPO1), the major nuclear export receptor, is involved in the cellular adaptation to reduced oxygen availability by controlling the nuclear activity of the hypoxia-inducible factors (HIFs). Recently, a specific inhibitor of XPO1, selinexor (KPT-330), has been identified that inhibits nuclear export of cargo proteins by binding to the XPO1 cargo-binding pocket.