Open Access<p>NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma</p>
Author(s) -
Yu Guo,
Li-Chang Yang,
Shaorong Lei,
Wuyuan Tan,
J Long
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s212317
Subject(s) - nedd4 , ubiquitin , cancer research , immune system , melanoma , medicine , tumor microenvironment , chemistry , ubiquitin ligase , immunology , biochemistry , gene
Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma.