Open Access<p>Utility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer</p>
Author(s) -
Yunzhang Hu,
Yapei Zhu,
Wen Zhang,
Jinghe Lang,
Ning Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s211413
Subject(s) - medicine , receiver operating characteristic , biomarker , epithelial ovarian cancer , ovarian cancer , cohort , oncology , stage (stratigraphy) , area under the curve , gastroenterology , endometrial cancer , cancer , pathology , biology , paleontology , biochemistry , chemistry
Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer death in women. Due to a lacking of early detection method, its five-year survival rate is only 30%. Nevertheless, novel biomarkers for diagnosis remain to be discovered. The potential of microRNA signatures in the diagnosis of EOC has been especially described in recent years. In our previous experiments, we identified that circBNC2 was downregulated in EOC specimens, and was associated with advanced tumor stage and lymph node metastasis (LNM) by performing circRNA-sequencing analysis. The aim of this study was to explore the diagnostic value of circBNC2 in patients with epithelial ovarian cancer (EOC).