<p>Differential Expression And Effects Of Peroxiredoxin-6 On Drug Resistance And Cancer Stem Cell-Like Properties In Non-Small Cell Lung Cancer</p>
Author(s) -
Jiaman Xu,
Qiang Su,
Mingxia Gao,
Qingsong Liang,
Junfeng Li,
Xu Chen
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s211125
Subject(s) - cisplatin , cancer stem cell , wnt signaling pathway , cancer research , lung cancer , flow cytometry , gene silencing , viability assay , abcg2 , immunohistochemistry , cancer , cell , chemistry , microbiology and biotechnology , biology , medicine , pathology , signal transduction , chemotherapy , biochemistry , atp binding cassette transporter , transporter , gene
Cancer stem-like cells (CSC) are thought to be involved in the cisplatin resistance of tumors. This study was designed to investigate the effect of PRDX6 on CSCs present in cisplatin-resistant non-small cell lung cancer (NSCLC) tumors.