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Pulmonary sarcomatoid carcinoma (PSC) is a rare and poorly differentiated type of non-small cell lung cancer (NSCLC) with specific characteristics, which usually presents a challenge in clinical practice. Mesenchymal-epithelial transition ( MET ) gene has been identified as a promising target for treatments in the past few years. Here, we report a case of a patient with PSC harboring MET exon 14 mutation, who responded to a novel MET inhibitor - savolitinib.

oncotargets and therapy

&lt;p&gt;Response and acquired resistance to savolitinib in a patient with pulmonary sarcomatoid carcinoma harboring &lt;em&gt;MET&lt;/em&gt; exon 14 skipping mutation: a case report&lt;/p&gt;