Open Access<p>Sodium Selenite Improves The Therapeutic Effect Of BMSCs Via Promoting The Proliferation And Differentiation, Thereby Promoting The Hematopoietic Factors</p>
Author(s) -
Dongmei Yan,
Botao Tang,
Lei Yan,
Lei Zhang,
Meijuan Miao,
Xi Chen,
Guangyi Sui,
Qi Zhang,
Daoyuan Liu,
Hui Wang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s209937
Subject(s) - chemistry , adipogenesis , mesenchymal stem cell , microbiology and biotechnology , selenium , cell growth , cd90 , cd44 , apoptosis , runx2 , bone marrow , reactive oxygen species , andrology , cell , in vitro , immunology , osteoblast , biochemistry , biology , medicine , organic chemistry
Sodium selenite (Na 2 SeO 3 ) has been known to restore the antioxidant capacity of bone marrow mesenchymal stem cells (BMSCs), reduce the production of reactive oxygen species (ROS) in the cells, and promote cell proliferation and inhibit cell apoptosis. However, it is still not clear whether selenium can mediate the differentiation and inhibit the induced hemagglutination of BMSCs. In this study, we attempted to explore the effect of Na 2 SeO 3 on these aspects of BMSCs.