Open Access<p>The better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells</p>
Author(s) -
Xiaojun Xiao,
Yujuan Zhang,
Lin Qi,
Keli Zhong
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s209692
Subject(s) - apoptosis , cell cycle , pi3k/akt/mtor pathway , transfection , hela , cell growth , cancer research , annexin , cell , protein kinase b , medicine , chemistry , cell culture , biology , biochemistry , genetics
Cervical cancer is the second leading cause of women's cancer-related death. MiR-940 has been reported as a critical factor in various cancers. Based on the high transfection efficiency and low side effect, the clinical application of microbubble ultrasound contrast agent in gene treatment has attracted a widespread attention. In this study, we determined the mechanism of miR-940 inhibiting cell proliferation and cycle procession, and promoting cell apoptosis in cervical cancer Hela cells. In addition, we compared the effects of different transfection methods, including liposome, microbubble, ultrasound, and microbubble coupled with ultrasound.