Open Access<p>Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer</p>
Author(s) -
Yan Zeng,
Chenglong Wang,
Jie Xian,
Yue Qian,
Qiang Xue,
Yiwen Tan,
Youde Cao
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s209484
Subject(s) - triple negative breast cancer , immunohistochemistry , breast cancer , medicine , immune system , biomarker , pd l1 , cancer , staining , correlation , pathology , cancer research , oncology , immunotherapy , biology , immunology , biochemistry , geometry , mathematics
Tumors with high mutation load tend to have a stronger immune response in some tumors. The correlation between expression of programmed death ligand-1 (PD-L1), a biomarker of immune response in tumors, and p53, accepted as the most frequently mutated gene in many cancers, in triple-negative breast cancer (TNBC) has not been fully investigated in cancer patients.