Open Access<p>Emerging roles of circular RNAs in colorectal cancer</p>
Author(s) -
Shuhong Hao,
Cong Liu,
Rongfeng Qu,
Rui Liu,
Guizhen Zhang,
Yarong Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s208235
Subject(s) - colorectal cancer , cancer , biomarker , circular rna , competing endogenous rna , microrna , biology , diagnostic biomarker , computational biology , cancer research , mechanism (biology) , bioinformatics , medicine , long non coding rna , rna , gene , genetics , philosophy , epistemology
Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs. Owing to the development of high-throughput sequencing, researchers have identified thousands of circRNAs. Emerging evidence suggests that circRNAs are involved in various tumor cell processes, including proliferation, apoptosis, invasion and migration. Because of their high stability and abundance, tissue-specific expression, and easy detection, circRNAs are considered ideal biomarkers for cancer diagnosis and prognosis. An increasing number of studies have recently demonstrated that circRNAs are closely associated with colorectal cancer (CRC). CRC is the third most common cancer and the second leading cause of cancer-related death globally. Thus, understanding the molecular mechanisms involved in the development and progression of CRC is vital. In this review, we summarize the current literature regarding human circRNAs related to CRC and present an overview of the potential clinical implications of circRNAs with respect to CRC.