Open Access<p>In vitro Transport Ability of <em>ABCC2</em> (G1249A) Polymorphic Variant Towards Anticancer Drugs</p>
Author(s) -
Linxin Guo,
Jia Yuan,
Yuan Gao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s207613
Subject(s) - paclitaxel , multidrug resistance associated protein 2 , doxorubicin , efflux , docetaxel , transfection , pharmacology , intracellular , cell culture , chemistry , microbiology and biotechnology , biology , transporter , atp binding cassette transporter , chemotherapy , biochemistry , genetics , gene
Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines.