Open Access<p>Biological Functions of TNKS1 and Its Relationship with Wnt/β-Catenin Pathway in Astrocytoma</p>
Author(s) -
Min Chen,
Bin Tang,
Shenhao Xie,
Jian Yan,
Liangle Yang,
Xinhui Zhou,
Erming Zeng
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s206142
Subject(s) - wnt signaling pathway , viability assay , gene knockdown , apoptosis , catenin , cancer research , cell growth , transfection , cell , u87 , immunoprecipitation , cell culture , chemistry , cell cycle , downregulation and upregulation , biology , signal transduction , glioma , microbiology and biotechnology , gene , biochemistry , genetics
Tankyrase1 (TNKS1), which often shows abnormal expression in many malignant tumor cells, plays an important role in tumor progression. In our previous study, we found that TNKS1 is also closely related to pathologic grade in human astrocytoma and its expression level is positively correlated with the Wnt/β-catenin pathway. This study is aimed to further elucidate the biological functions of TNKS1 as well as its relationship with the Wnt/β-catenin pathway.