Open Access<p>Elevated <em>HOXA13</em> expression promotes the proliferation and metastasis of gastric cancer partly via activating Erk1/2</p>
Author(s) -
Zhiwei Qin,
Zhengqian Chen,
Junyong Weng,
Shanbao Li,
Zeyin Rong,
Chongzhi Zhou
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s196986
Subject(s) - gene knockdown , vimentin , microbiology and biotechnology , cyclin d1 , downregulation and upregulation , western blot , epithelial–mesenchymal transition , cancer research , biology , chemistry , cell cycle , cell , cell culture , immunohistochemistry , immunology , gene , genetics
HOXA13 is a transcription factor of the Homeobox ( HOX ) gene family, which is highly evolutionarily conserved. HOXA13 is upregulated and associated with oncogenic properties in some cancers. Here, we studied the potential mechanism of HOXA13 -mediated proliferation and metastasis in gastric cancer (GC).