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Osimertinib is the standard of care for patients with non-small-cell lung cancer (NSCLC) patients harboring acquired EGFR T790M resistance mutation. However, the frequency of T790M resistance mutation acquisition and the efficacy of osimertinib in patients harboring uncommon EGFR mutations, which accounts for approximately 10% of EGFR mutations, remain unclear.

oncotargets and therapy

&lt;p&gt;Acquisition of T790M resistance mutation in a patient with advanced adenocarcinoma harboring uncommon &lt;em&gt;EGFR&lt;/em&gt; mutations: a case report and literature review&lt;/p&gt;