Open AccessCUX2 functions as an oncogene in papillary thyroid cancer
Author(s) -
Yihan Sun,
Danrong Ye,
Yuefeng Li,
Endong Chen,
Rutian Hao,
Yefeng Cai,
Qingxuan Wang,
Ouchen Wang,
Xiaohua Zhang
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s185710
Subject(s) - oncogene , cancer research , pi3k/akt/mtor pathway , papillary thyroid cancer , thyroid cancer , gene silencing , thyroid carcinoma , cancer , medicine , thyroid function , malignancy , protein kinase b , oncology , thyroid , biology , apoptosis , genetics , cell cycle , gene
In recent years, the incidence of thyroid cancer (TC), the most common endocrine malignancy, has been increasing. Emerging evidence indicates that the CUT/CUX/CDP family of proteins can play an important role in tumor development and progression by regulating many cancer-related functions. However, the molecular functions of CUX2 in TC remain unknown.