Open Access<p>MDM2 promotes epithelial–mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma</p>
Author(s) -
Yong Tang,
Yiwen Xuan,
Guibin Qiao,
Zhu’an Ou,
Zhe He,
Quangang Zhu,
Ming Juan Liao,
Guilin Yin
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s185076
Subject(s) - epithelial–mesenchymal transition , mdm2 , gene knockdown , a549 cell , cancer research , vimentin , transfection , smad , gene silencing , small interfering rna , downregulation and upregulation , signal transduction , biology , cell growth , chemistry , apoptosis , cell culture , microbiology and biotechnology , immunology , biochemistry , gene , immunohistochemistry , genetics
Mouse double minute 2 (MDM2) contributes to cancer metastasis and epithelial-mesenchymal transition (EMT). This study aimed to investigate small mothers against decapentaplegic (Smad) signaling in MDM2-mediated EMT in lung adenocarcinoma (LAC).