Open Access<p>Downregulation of survivin by adenovirus-mediated shRNA promotes apoptosis in skin cancer cells</p>
Author(s) -
Yuqin Hao,
Xuefeng Bai,
Xia Liu,
Shuxia Kang,
Xin Zhang,
Caiyun Liu,
Zhehai Li
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s162150
Subject(s) - survivin , cancer research , apoptosis , small hairpin rna , cancer cell , cancer , mtt assay , cell cycle , cell growth , downregulation and upregulation , chemistry , gene knockdown , microbiology and biotechnology , medicine , biology , biochemistry , gene
Survivin, a member of the inhibitor of apoptosis protein family, is highly expressed in many cancers and has important roles in inhibiting apoptosis by blocking caspase activation. However, its antitumor effects remain largely unknown. Here we explore the function of survivin in skin cancer.