Open AccessMFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway
Author(s) -
Jiankai Wang,
WenJuan Wang,
Hao Cai,
Binbin Du,
Ping Mai,
Lijuan Zhang,
Wen Ma,
Youyou Hu,
Shi-Fang Feng,
Guoying Miao
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s160831
Subject(s) - epithelial–mesenchymal transition , cancer research , cancer , signal transduction , downregulation and upregulation , extracellular matrix , mesenchymal stem cell , chemistry , medicine , biology , pathology , microbiology and biotechnology , metastasis , gene , biochemistry
Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to play a significant role in obesity, diabetes, and osteopenia, and has been shown to be upregulated in head and neck squamous cell carcinoma. However, the molecular function and prognostic value of MFAP2 have never been reported in gastric cancer (GC) or any other tumors.