Open AccessSIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion
Author(s) -
Hongjie Sun,
Dongli Huang,
Guozheng Liu,
Fengguo Jian,
Jingjing Zhu,
Lixia Zhang
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s156143
Subject(s) - cancer research , cell growth , suppressor , epithelial–mesenchymal transition , cancer , blot , cell migration , biomarker , real time polymerase chain reaction , metastasis , cell , chemistry , biology , microbiology and biotechnology , biochemistry , gene , genetics
Previous study has proven that SIRT4 is downregulated in gastric cancer (GC), but the role of SIRT4 has not been clearly understood. The aim of our work was to explore in detail the function and mechanism of SIRT4 in GC.