Open AccessThe clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis
Author(s) -
Chaojie Liang,
Xu Yang,
Hua Ge,
Guangming Li,
Jixiang Wu
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s154227
Subject(s) - medicine , meta analysis , hepatocellular carcinoma , oncology , cochrane library , hsp27 , hazard ratio , biomarker , forest plot , stage (stratigraphy) , incidence (geometry) , disease , cancer , confidence interval , biology , heat shock protein , hsp70 , biochemistry , paleontology , physics , optics , gene
In the recent past, there is increasing evidence demonstrating that HSP27 plays a key role in tumor progression. However, the relationship between HSP27 expression and the clinicopathological features of hepatocellular carcinoma (HCC), as well as its prognostic value in HCC patients remain controversial. Accordingly, we conducted a meta-analysis to assess the correlation between HSP27 expression and HCC, and determine the prognostic value of HSP27 in HCC.