Open AccessGenetic variation <em>rs7930 </em>in the miR-4273-5p target site is associated with a risk of colorectal cancer
Author(s) -
Ah-Reum Lee,
JongKeun Park,
Yeon Jung Kim,
Sung-Joo KimYoon
Publication year - 2016
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s108787
Subject(s) - single nucleotide polymorphism , microrna , colorectal cancer , snp , gene , genetics , biology , oncology , medicine , cancer , bioinformatics , genotype
MicroRNAs (miRNAs) are noncoding RNAs that play roles as tumor suppressors or oncogenes by regulating the expression of target genes via binding to seed-match sequences. Polymorphisms in the miRNA-binding site of a target gene can alter miRNA binding and potentially affect the risk of cancer. The objective of this study was to identify single-nucleotide polymorphisms (SNPs) in miRNA-binding sites and assess their involvement in the risk of colorectal cancer (CRC).