Open AccessThe Effect of Platelet-Rich Plasma on Type I Collagen Production, VEGF Expression, and Neovascularization after Femoral Bone Implants: A Study on Rat Models
Author(s) -
Safrizal Rahman,
Endang Sutedja,
Onarisa Ayu,
Mirnasari Amirsyah
Publication year - 2022
Publication title -
orthopedic research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.707
H-Index - 9
ISSN - 1179-1462
DOI - 10.2147/orr.s359844
Subject(s) - neovascularization , platelet rich plasma , type i collagen , immunohistochemistry , medicine , angiogenesis , endocrinology , platelet , chemistry , andrology , pathology
Platelet-rich plasma (PRP) contains many growth factors, such as FGF, which induces the production of type I collagen, and VEGF, which induces neovascularization, all of which are important in bone healing. This study aimed to evaluate the effect of PRP administration on type I collagen production, VEGF expression, and neovascularization in rat models following femoral bone implants using K-wire.