Open AccessA Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice
Author(s) -
Shigeto Maekawa,
Kota Sato,
Taiki Kokubun,
Noriko Himori,
Takeshi Yabana,
Michiko Ohno-Oishi,
Ge Shi,
Kazuko Omodaka,
Toru Nakazawa
Publication year - 2022
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s354958
Subject(s) - neuroprotection , antioxidant , pharmacology , calpain , retinal ganglion cell , tunel assay , tbars , medicine , apoptosis , retinal , chemistry , biochemistry , lipid peroxidation , enzyme
To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds on the involvement of calpain inactivation.