Open AccessStratification-Based Investigation of Adjunctive Brimonidine or Timolol to a Prostaglandin Analogue in Japanese Patients with Normal-Tension Glaucoma
Author(s) -
Keiji Yoshikawa,
Shiro Mizoue,
Koji Nitta,
Hiroshi Onishi,
Masaharu Ikeda,
Akemi Mizuno,
Kaori Kawazoe,
Yoshiyuki Tamada,
Ryuji Takeda,
Shun Matsumoto
Publication year - 2021
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s318392
Subject(s) - medicine , brimonidine , timolol , ophthalmology , intraocular pressure , latanoprost , normal tension glaucoma , glaucoma , travoprost , bimatoprost , prostaglandin analogue , post hoc analysis , open angle glaucoma
We previously investigated the efficacy and safety of adding 0.1% brimonidine (Brim) or 0.5% timolol (Tim) to prostaglandin analogue (PGA) monotherapy to treat patients with normal-tension glaucoma (NTG) with intraocular pressure (IOP) of ≤16 mmHg. Herein, we describe an additional post-hoc stratifying analysis of the possible differences in the effect of IOP-lowering and pulse rate (PR) after adjunctive Brim or Tim to PGA.