Open AccessGene Expression Profiling of Monozygotic Twins Affected by Psoriatic Arthritis
Author(s) -
Maria Maddalena Angioni,
Alberto Floris,
Ignazio Cangemi,
Mattia Congia,
Elisabetta Chessa,
Sandro Orrù,
Matteo Piga,
Alberto Cauli
Publication year - 2021
Publication title -
open access rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 14
ISSN - 1179-156X
DOI - 10.2147/oarrr.s291391
Subject(s) - epigenomics , transcriptome , epigenetics , monozygotic twin , psoriatic arthritis , gene expression profiling , candidate gene , disease , phenotype , gene , medicine , biology , genetics , bioinformatics , gene expression , pathology , dna methylation
Psoriatic Arthritis (PsA) is a multifactorial disease, where the relative burden of genetic, epigenetic and environmental factors in clinical course and damage accrual is not yet definitively clarified. In clinical practice, there is a real need for useful candidate biomarkers in PsA diagnosis and disease progression, by exploring its underlying transcriptomic and epigenomic mechanisms. This work aims to profile the transcriptome in monozygotic (MZ) twins with psoriatic arthritis (PsA) highly concordant for clinical presentation, but discordant for the radiographic outcomes' severity.