Open Accessα7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Ameliorates Cognitive Impairment Induced by Chronic Intermittent Hypoxia
Author(s) -
Hui Shen,
Yanyan Meng,
Dan Liú,
Zheng Qin,
Hong Huang,
Lei Pan,
Wei Wang,
Jian Kang
Publication year - 2021
Publication title -
nature and science of sleep
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.715
H-Index - 34
ISSN - 1179-1608
DOI - 10.2147/nss.s296701
Subject(s) - morris water navigation task , medicine , creb , agonist , methyllycaconitine , endocrinology , hippocampal formation , tunel assay , intermittent hypoxia , receptor , acetylcholine receptor , obstructive sleep apnea , nicotinic acetylcholine receptor , immunohistochemistry , biology , biochemistry , transcription factor , gene
Cognitive impairment is an important complication of obstructive sleep apnea (OSA). Chronic intermittent hypoxia (CIH), the main pathophysiological characteristics of OSA, is closely related to cognitive dysfunction and may be mediated by alpha-7 nicotinic acetylcholine receptors (α7nAChR). This study investigated the effects and clarified the mechanisms of α7nAChR on the cognitive function of mice with CIH.