Open AccessClosed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers
Author(s) -
Christian S. Guay,
Alyssa K. Labonte,
Michael C. Montana,
Eric C. Landsness,
Brendan P. Lucey,
MohammadMehdi Kafashan,
Simon Haroutounian,
Michael S. Avidan,
Emery N. Brown,
Ben Julian A. Palanca
Publication year - 2021
Publication title -
nature and science of sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.715
H-Index - 34
ISSN - 1179-1608
DOI - 10.2147/nss.s293160
Subject(s) - dexmedetomidine , medicine , sedation , anesthesia , electroencephalography , crossover study , bispectral index , sedative , audiology , psychiatry , alternative medicine , pathology , placebo
The relative power of slow-delta oscillations in the electroencephalogram (EEG), termed slow-wave activity (SWA), correlates with level of unconsciousness. Acoustic enhancement of SWA has been reported for sleep states, but it remains unknown if pharmacologically induced SWA can be enhanced using sound. Dexmedetomidine is a sedative whose EEG oscillations resemble those of natural sleep. This pilot study was designed to investigate whether SWA can be enhanced using closed-loop acoustic stimulation during sedation (CLASS) with dexmedetomidine.