Open Access<p>Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid</p>
Author(s) -
Hui Li,
Yanlong Liu,
Lifei Xing,
Xiaoyu Yang,
Jinzhong Xu,
Qiushi Ren,
KuanPin Su,
Yanye Lu,
Wei Fan
Publication year - 2020
Publication title -
nature and science of sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.715
H-Index - 34
ISSN - 1179-1608
DOI - 10.2147/nss.s272883
Subject(s) - medicine , cerebrospinal fluid , pittsburgh sleep quality index , serotonin , serotonin transporter , dopamine transporter , dopamine , sleep disorder , radioimmunoassay , endocrinology , smoking cessation , anesthesia , gastroenterology , psychiatry , dopaminergic , sleep quality , pathology , insomnia , receptor
Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF).