Open AccessPharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids
Author(s) -
Ron Firestein,
Cezary Marcinkiewicz,
Linyan Nie,
H. Chua,
Ines Velazquez Quesada,
Marco D. Torelli,
Mark Sternberg,
Bojana Gligorijevic,
Olga Shenderova,
Romana Schirhagl,
Giora Feuerstein
Publication year - 2021
Publication title -
nanotechnology, science and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.051
H-Index - 28
ISSN - 1177-8903
DOI - 10.2147/nsa.s321725
Subject(s) - doxorubicin , organoid , cancer cell , colorectal cancer , chemistry , apoptosis , cancer research , cancer , liver cancer , flow cytometry , confocal microscopy , pharmacology , fluorescence microscope , microbiology and biotechnology , biology , chemotherapy , medicine , biochemistry , fluorescence , physics , quantum mechanics
We recently reported on preferential deposition of bare fluorescent diamond particles FDP-NV-700/800nm (FDP-NV) in the liver following intravenous administration to rats. The pharmacokinetics of FDP-NV in that species indicated short residency in the circulation by rapid clearance by the liver. Retention of FDP-NV in the liver was not associated with any pathology. These observations suggested that cancer therapeutics, such as doxorubicin, linked to FDP-NV, could potentially serve for anti-cancer treatment while sparing toxicities of peripheral organs.