Open AccessUptake and Intracellular Trafficking Studies of Multiple Dye-Doped Core-Shell Silica Nanoparticles in Lymphoid and Myeloid Cells
Author(s) -
Federica Sola,
Barbara Caico,
Mariele Montanari,
Angela Volpe,
Chiara Barattini,
C. Pellegrino,
Erica Cesarini,
Michele Guescini,
Michela Battistelli,
Claudio Ortolani,
Alfredo Ventola,
Stefano Papa
Publication year - 2021
Publication title -
nanotechnology, science and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.051
H-Index - 28
ISSN - 1177-8903
DOI - 10.2147/nsa.s290867
Subject(s) - nanomaterials , nanotechnology , förster resonance energy transfer , chemistry , biophysics , intracellular , internalization , nanoparticle , flow cytometry , confocal microscopy , mesoporous silica , fluorescence , materials science , cell , microbiology and biotechnology , biochemistry , biology , mesoporous material , physics , quantum mechanics , catalysis
Since most biologically active macromolecules are natural nanostructures, operating in the same scale of biomolecules gives the great advantage to enhance the interaction with cellular components. Noteworthy efforts in nanotechnology, particularly in biomedical and pharmaceutical fields, have propelled a high number of studies on the biological effects of nanomaterials. Moreover, the determination of specific physicochemical properties of nanomaterials is crucial for the evaluation and design of novel safe and efficient therapeutics and diagnostic tools. In this in vitro study, we report a physicochemical characterisation of fluorescent silica nanoparticles (NPs), interacting with biological models (U937 and PBMC cells), describing the specific triggered biologic response.