Open AccessAssociations of Serum Cytokines, Growth Factors, and High-Sensitivity C-Reactive Protein Levels in Patients with Major Depression with and without Type 2 Diabetes Mellitus: An Explanatory Investigation
Author(s) -
Takashi Hoshikawa,
Naomichi Okamoto,
Tomoya Natsuyama,
Rintaro Fujii,
Atsuko Ikenouchi,
Yuichi Honma,
Masaru Harada,
Reiji Yoshimura
Publication year - 2022
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s350121
Subject(s) - medicine , depression (economics) , diabetes mellitus , type 2 diabetes mellitus , type 2 diabetes , c reactive protein , endocrinology , inflammation , economics , macroeconomics
We investigated the serum levels of cytokines, including interleukin 1β (IL-β), IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and growth factors, including brain-derived neurotrophic factor, vascular endothelial growth factor, and insulin-like growth factor 1, and their association with major depression in patients with and without type 2 diabetes mellitus. We also investigated the response to antidepressant treatment in both groups.