Open AccessAbnormalities of Gray Matter Volume and Its Correlation with Clinical Symptoms in Adolescents with High-Functioning Autism Spectrum Disorder
Author(s) -
Xiaojie Zhao,
Shuyi Zhu,
Yang Cao,
Peipei Cheng,
Yuxiong Lin,
Zhixin Sun,
Wenqing Jiang,
Yasong Du
Publication year - 2022
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s349247
Subject(s) - autism spectrum disorder , voxel based morphometry , medicine , frontal lobe , cerebellum , audiology , magnetic resonance imaging , correlation , inferior temporal gyrus , superior frontal gyrus , temporal lobe , autism , psychiatry , white matter , epilepsy , radiology , geometry , mathematics
Previous studies have indicated abnormal gray matter volume (GMV) in individuals with autism spectrum disorder (ASD); however, there is little consistency across the findings within these studies, partly due to small sample size and great heterogeneity among participants between studies. Additionally, few studies have explored the correlation between clinical symptoms and GMV abnormalities in individuals with ASD. Here, the current study examined GMV alterations in whole brain and their correlations with clinical symptoms in a relatively large and homogeneous sample of participants with ASD matched typically developing (TD) controls.