Open AccessLack of Association of FLT3 rs2504235 and Absence of SLITRK1 var321 in Patients with Tic Disorders from Guangdong Province, China
Author(s) -
Ming Gao,
Huakuan Lin,
Bingxiao Li,
Junjie Wen,
Yingying Wang,
ZhanHui Zhang,
Wenxiong Chen
Publication year - 2022
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s340197
Subject(s) - medicine , sanger sequencing , genotype , single nucleotide polymorphism , genetics , tourette syndrome , allele , cohort , genome wide association study , genomic dna , genetic association , gene , biology , dna sequencing , psychiatry
Tic disorders (TDs) are highly polygenic and heritable neurodevelopmental disorders characterized by the presence of movements (motor tics) and/or vocalizations (phonic tics). SLITRK1 is a pathogenic variation of TD, and in a recent genome-wide association study in those of European ancestry, a single-nucleotide polymorphism (rs2504235) in the FLT3 gene was significantly associated with TDs/Tourette's syndrome. However, these results need to be proved in different populations. This study aimed to determine whether these two genetic variants were also associated with TD patients in south China.