Open AccessAssociation of Versican Gene Polymorphisms with Intracranial Aneurysm Susceptibility in the Eastern Chinese Population
Author(s) -
Zhu Lei,
Chuanqing Yu,
Shuping Zhou,
Min Xue,
Jie Chen,
Mei-jun Wu,
Shengjie Dong,
Guanmin Huang,
Yueyue Chang,
Mei Zhang
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s338311
Subject(s) - single nucleotide polymorphism , medicine , genotype , versican , snp , genotyping , allele , odds ratio , genetics , snp genotyping , genetic predisposition , population , allele frequency , oncology , gene , biology , anatomy , proteoglycan , cartilage , disease , environmental health
The proteoglycan versican (VCAN) plays an important role in extracellular matrix (ECM) assembly, and diminished maintenance of the ECM has been increasingly regarded as an important factor in the development of intracranial aneurysms (IAs). Previous studies have revealed that single-nucleotide polymorphisms (SNPs) of the VCAN gene are associated with susceptibility to IAs in European or Japanese populations. However, the association between IA susceptibility and VCAN SNPs in the Eastern Chinese population remains unclear. This study aimed to investigate the associations of the SNPs rs251124, rs2287926, and rs173686 with IA susceptibility in the Eastern Chinese population.