Open AccessReduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
Author(s) -
Toshiyuki Ohtani,
Koji Matsuo,
Chihiro Sutoh,
Fumiyo Oshima,
Yoshiyuki Hirano,
Akio Wakabayashi,
Eiji Shimizu
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s327608
Subject(s) - ventrolateral prefrontal cortex , autism spectrum disorder , medicine , depression (economics) , prefrontal cortex , audiology , functional neuroimaging , functional near infrared spectroscopy , neuroimaging , haemodynamic response , clinical psychology , neuroscience , cognition , autism , psychiatry , psychology , heart rate , blood pressure , economics , macroeconomics
In clinical settings, diagnosing comorbid depression in individuals with autism spectrum disorder (ASD) is often difficult. Neuroimaging studies have reported reduced activation of frontal and temporal regions during emotional face recognition task (EFRT) in ASD and depression. However, to the best of our knowledge, no study has examined differences in frontotemporal activation during EFRT between ASD with and without comorbid depression. We aimed to compare the frontotemporal hemodynamic responses to the EFRT in ASD with and without depression and to find clues to help in discriminating the characteristics between them.