Open AccessAssociation Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
Author(s) -
Bénédicte Nobile,
Émilie Olié,
Nicolás Ramoz,
Jonathan Dubois,
Sébastien Guillaume,
Philip Gorwood,
Philippe Courtet
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s324868
Subject(s) - medicine , depression (economics) , cohort , suicidal ideation , hospital anxiety and depression scale , psychiatry , prospective cohort study , anxiety , poison control , injury prevention , macroeconomics , environmental health , economics
Growing evidences suggest that depression with suicidal ideation (SI) could be a specific phenotype with its own characteristics. Moreover, opioid system deregulation might be implicated in suicidal behaviour (SB). The aim of this study was to determine whether the A118G polymorphism (rs1799971) in ORPM1 (the gene encoding opioid receptor mu 1) is associated with suicidal depression (ie, moderate to severe depression with SI) in a large cohort of outpatients with depression.