Open AccessRole of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)
Author(s) -
Jintana Sirivarasai,
Kanchaporn Chaisungnern,
Pachara Panpunuan,
Suwannee Chanprasertyothin,
Sirintorn Chansirikanjana,
Piyamitr Sritara
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s320374
Subject(s) - montreal cognitive assessment , medicine , single nucleotide polymorphism , body mass index , genotype , genetics , dementia , biology , gene , disease
Many age-related structural and functional changes in the brain have important consequences. Long-term exposure to mercury and the impact of functional polymorphisms of metal-regulating proteins such as metallothioneins (MTs) can result in neurological-neurobehavioral effects in elderly individuals. Therefore, the aims of this study are to examine the associations between biomarkers of mercury exposure and cognitive impairment and to investigate the effect of the rs8052394 single nucleotide polymorphism (SNP) of the potential modifier gene MT1A on different domains of the Montreal Cognitive Assessment (MoCA).