Open AccessAssociation Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect
Author(s) -
Xiaotong Song,
Ning Sun,
Aixia Zhang,
Lei Lei,
Xinrong Li,
Zhifen Liu,
Yanfang Wang,
Chunxia Yang,
Kerang Zhang
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s319548
Subject(s) - antidepressant , single nucleotide polymorphism , major depressive disorder , medicine , depression (economics) , dopaminergic , psychiatry , genotype , oncology , bioinformatics , anxiety , genetics , gene , biology , dopamine , mood , macroeconomics , economics
Although the pathogenesis of major depressive disorder (MDD) is still unclear, studies have shown that the dopaminergic system of depressed patients is defective, and that NR4A2 is an important transcription factor affecting the development and maintenance of dopaminergic neurons. As such, NR4A2 levels affected by NR4A2 single nucleotide polymorphisms (SNPs) may be associated with MDD. This study examined whether NR4A2 SNPs are associated with depressive symptoms and antidepressant efficacy.