Open AccessInhibition of miR-448-3p Attenuates Cerebral Ischemic Injury by Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)
Author(s) -
Min Xu,
Dingchao Xiang,
Wenhua Wang,
Long Long Chen,
Wei Lu,
Cheng Feng
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s310495
Subject(s) - neuroprotection , oxidative stress , western blot , apoptosis , viability assay , downregulation and upregulation , medicine , tunel assay , in vivo , pharmacology , gene silencing , microbiology and biotechnology , biology , biochemistry , gene
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator responsible for oxidative stress in brain injury. This study aimed to investigate the potential mechanism of miR-448-3p and Nrf2 in cerebral ischemia/reperfusion (I/R) injury.