Open AccessEffect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats
Author(s) -
Anna Wesołowska,
Joanna Rychtyk,
Joanna GdulaArgasińska,
Katarzyna Górecka,
Natalia Wilczyńska-Zawal,
Magdalena Jastrzębska-Więsek,
Anna Partyka
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s309818
Subject(s) - anxiolytic , haloperidol , medicine , pharmacology , antidepressant , risperidone , prefrontal cortex , brain derived neurotrophic factor , serotonergic , agonist , hippocampus , neurotrophic factors , schizophrenia (object oriented programming) , psychiatry , receptor , dopamine , serotonin , cognition
The presence of depressive and anxiety symptoms in patients with schizophrenia may have an important impact on treatment and compliance. Hence, interventions addressing such comorbidity in schizophrenia should be explored. One target may be a serotonergic 5-HT 6 receptor (5-HT 6 R) since its ligands displayed antidepressant- and anxiolytic-like activities in preclinical experiments.