Open AccessInterleukin-6 in Cerebrospinal Fluid Small Extracellular Vesicles as a Potential Biomarker for Prognosis of Aneurysmal Subarachnoid Haemorrhage
Author(s) -
YungHun Yang,
Xinggen Fang,
Jiaying Yuan,
Feiyun Qin,
Tao Yu,
Dayong Xia,
Zhenbao Li,
Niansheng Lai
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s304394
Subject(s) - medicine , biomarker , subarachnoid hemorrhage , cerebrospinal fluid , stroke (engine) , receiver operating characteristic , logistic regression , extracellular vesicles , prospective cohort study , disease , gastroenterology , mechanical engineering , biochemistry , chemistry , engineering , biology , microbiology and biotechnology
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe form of stroke characterized by high rates of mortality and disability. Identifying circulating biomarkers is helpful to improve outcomes. In this study, for the first time, we identify interleukin-6 (IL-6) in cerebrospinal fluid (CSF) small extracellular vesicles (sEVs) as potential biomarkers for prognosis of aSAH.