Open AccessTraditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus
Author(s) -
Jiao Hu,
Hongjun Yang,
Zhonghua Yan,
Jianbei Chen,
Mengbai Xu,
You-Ming Jiang,
Yueyun Liu,
Zhe Xue,
Qingyu Ma,
Xiaojuan Li,
Jiaxu Chen
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s302443
Subject(s) - medicine , hippocampus , depression (economics) , pathogenesis , fluoxetine , receptor , serotonin , economics , macroeconomics
At present, the pathogenesis of depression is not fully understood, and nearly half of depression patients experience no obvious effects during treatment. This study aimed to establish a depression mouse model to explore the possible role of ferroptosis in the pathogenesis of depression, and observe the effects of Xiaoyaosan on PEBP1-GPX4-mediated ferroptosis in the hippocampus.