Open AccessVagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
Author(s) -
Lína Zhang,
Xianwei Zhang,
Changqing Li,
Jing Guo,
Yongping Chen,
Shengli Chen
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s300535
Subject(s) - autophagy , neuroprotection , medicine , apoptosis , ischemia , stimulation , reperfusion injury , vagus nerve stimulation , pharmacology , vagus nerve , anesthesia , neuroscience , biology , biochemistry
Cumulative evidence suggests that neuronal death including autophagy, apoptosis, and necrosis is closely related to the occurrence and development of cerebral ischemia-reperfusion (I/R) injury. Moreover, vagal nerve stimulation (VNS) is involved in many different neuroprotective and neuroplasticity pathways. Thus, VNS may be a novel approach for treating various neurodegenerative diseases. The present study aims to determine whether VNS protects against cerebral I/R injury in rats by inhibiting autophagy and apoptosis.