Open AccessRecruitment Challenges for Studies of Deep Brain Stimulation for Treatment-Resistant Depression
Author(s) -
Rajamannar Ramasubbu,
Sandra Golding,
Kimberly Williams,
Aaron Mackie,
Glenda MacQueen,
Zelma Kiss
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s299913
Subject(s) - medicine , referral , deep brain stimulation , depression (economics) , clinical trial , randomized controlled trial , major depressive disorder , treatment resistant depression , patient recruitment , psychiatry , family medicine , physical therapy , mood , disease , parkinson's disease , economics , macroeconomics
Deep brain stimulation (DBS) is currently an investigational treatment for treatment-resistant depression (TRD). There is a need for more DBS trials to strengthen existing evidence of its efficacy for both regulatory and clinical reasons. Recruitment for DBS trials remains challenging due to unproven efficacy in sham-controlled DBS trials, invasive nature of the intervention and stringent eligibility criteria in patient selection. Here, we examined the referral patterns and reasons for exclusion of subjects in our DBS trial.