Open AccessMechanism of Autophagy Regulation in MPTP-Induced PD Mice via the mTOR Signaling Pathway by Echinacoside
Author(s) -
Zhen-Nian Zhang,
Hui Zhang,
Chang Chen,
Yan Liang,
Lili Tang,
SuLei Wang,
Chengcheng Xu,
Hui Yang,
Yang Zhao,
Jing-Si Zhang
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s299810
Subject(s) - autophagy , pi3k/akt/mtor pathway , mptp , protein kinase b , tyrosine hydroxylase , western blot , substantia nigra , medicine , parkinson's disease , rotenone , microbiology and biotechnology , endocrinology , dopamine , apoptosis , signal transduction , chemistry , biology , biochemistry , mitochondrion , disease , gene
The present study aimed to investigate the effect of echinacoside on autophagy-related indicators through the mTOR signaling pathway, especially the effect on the clearance of autophagy substrate P62 and α-synuclein, the core pathological products of Parkinson's disease (PD), to provide new strategies for the treatment of PD.