Open AccessLate-Onset Leukodystrophy Mimicking Hereditary Spastic Paraplegia without Diffuse Leukodystrophy on Neuroimaging
Author(s) -
Tongxia Zhang,
Chuanzhu Yan,
Yiming Liu,
Lili Cao,
Kunqian Ji,
Duoling Li,
Chi L,
Yuying Zhao
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s296424
Subject(s) - hereditary spastic paraplegia , medicine , leukodystrophy , paraplegia , spastic quadriplegia , proband , pseudobulbar palsy , pediatrics , leukoencephalopathy , pathology , disease , physical therapy , psychiatry , mutation , cerebral palsy , genetics , spinal cord , gene , biology , phenotype
Leukodystrophies are frequently regarded as childhood disorders, but they can occur at any age, and the clinical and imaging patterns of the adult-onset form are usually different from the better-known childhood variants. Several reports have shown that various late-onset leukodystrophies, such as X-linked adrenoleukodystrophy and Krabbe disease, may present as spastic paraplegia with the absence of the characteristic white matter lesions on neuroimaging; this can be easily misdiagnosed as hereditary spastic paraplegia. The objective of this study was to investigate the frequency of late-onset leukodystrophies in patients with spastic paraplegia.